lovesickness

coincidence.

Nineteen psychedelics (2C-B, 2C-B-fly, DOB, DOI, DOM, 2C-E, 2C-T-2, ALEPH-2, Mescaline, MEM, MDA, MDMA, DMT, 5-MeO-DMT, 5-MeO-MIPT, DIPT, 5-MeO-DIPT, DPT, Psilocin) and three controls (lisuride 6-fluoro-DMT, 4C-T-2) have each been screened against the full panel of over one hundred receptors, transporters and ion channels by the National Institute of Mental Health Psychoactive Drug Screening Program (NIMH-PDSP), providing the first comprehensive view of how these compounds interact with the human receptome.

Each individual psychedelic causes a unique spectrum of subjective effects. DIPT causes auditory distortion. 5-MeO-DIPT enhances orgasm in males but not females. MDMA provokes empathy. TMA provokes anger. Mescaline provokes an appreciation of beauty. 2C-B causes tactile, gustatory and sexual enhancement. 2C-E provokes rich fantasy and introspection. Taken collectively, these compounds provide a rich set of tools for probing and revealing the chemical organization of the human brain and the mind that emerges from it.

The project aims to understand the mechanisms underlying the qualitative diversity of actions of psychedelics, by locating each drug in an abstract " receptor space", a coordinate system with one axis for each receptor. Drugs shift the balance of activity of the brain away from the origin, by a vector representing the profile of binding affinities at different receptors. Drugs perturb the system through increasing or decreasing transmission or transmitter levels, or up or down regulating receptor populations.

chemical architecture
lovesickness